Can I make Impossible Cheeseburger Pie ahead of time?

Absolutely! This dish reheats beautifully and actually tastes even better the next day as the flavors meld. Assemble the filling and Bisquick topping, then store covered in the fridge up to a day ahead. Just bake when ready to serve.

Can I use a different baking mix if I don’t have Bisquick?

Definitely. Any all-purpose baking mix should do the trick, or you can even use a homemade mix of flour, baking powder, a touch of salt, and a little butter or shortening.

What if I don’t eat beef—can I substitute another protein?

Yes! Ground turkey, chicken, or pork all work well. For a vegetarian twist, use plant-based meat crumbles. Just adjust the seasoning as needed for the best flavor.

How do I know when the pie is done baking?

You’re looking for a golden, puffed-up top and a center that’s set (not jiggly). A toothpick inserted into the Bisquick layer should come out mostly clean, and the edges will be nicely browned.

Impossible Cheeseburger Pie Recipe

Description

This Impossible Cheeseburger Pie is a quick and hearty classic that combines ground beef, cheddar cheese, and a savory Bisquick topping to create a delicious, family-friendly main course. It’s the perfect solution for busy weeknights — easy to prepare, super satisfying, and packed with comfort food flavors reminiscent of a cheeseburger.

Ingredients

Units Scale

For the Beef Mixture

1 1/2 pounds lean ground beef (80/20)
1 large onion, chopped
1 tsp minced garlic

For the Cheese Layer

1 cup cheddar cheese, shredded

For the Bisquick Topping

1/2 cup Bisquick
2 tbsp onion soup mix
2 eggs, room temp
1 cup milk

For Baking

Non-stick baking spray

Cook Mode Prevent your screen from going dark

Instructions

Prepare the Oven: Preheat the oven to 400 degrees F to ensure even baking for the pie.
Cook Beef Mixture: In a large skillet, add the ground beef, chopped onions, and minced garlic. Cook over medium heat, stirring frequently, until the beef is browned and the onions are translucent. This should take several minutes.
Drain Excess Grease: Carefully drain any excess grease from the cooked beef and onion mixture to avoid a soggy pie.
Prepare Baking Dish: Spray a 9-inch baking dish with non-stick baking spray to prevent sticking.
Add Beef and Cheese: Transfer the drained beef mixture into the prepared baking dish. Sprinkle the shredded cheddar cheese evenly over the beef layer to distribute the cheesy flavor throughout.
Mix Bisquick Batter: In a medium bowl, combine the Bisquick, onion soup mix, eggs, and milk. Whisk until the mixture is smooth and fully combined. This will form the pie’s topping.
Assemble Pie: Pour the Bisquick mixture evenly over the beef and cheese layer in the baking dish, ensuring full coverage.
Bake: Place the dish in the preheated oven and bake for 25 minutes or until the top is golden and the filling is set.
Garnish and Serve: Allow the pie to cool slightly, then garnish as desired before slicing and serving.

Notes

You can substitute ground turkey or chicken for a leaner version.
Add pickles, lettuce, or tomato as garnish to mimic classic cheeseburger toppings.
Store leftovers in an airtight container in the refrigerator for up to 3 days.
This pie reheats well in the microwave or oven.

Nutrition

Serving Size: 1/5 of pie
Calories: 493
Sugar: 6g
Sodium: 968mg
Fat: 29g
Saturated Fat: 12g
Unsaturated Fat: 15g
Trans Fat: 1g
Carbohydrates: 23g
Fiber: 1g
Protein: 35g
Cholesterol: 192mg